Nurses Who Saved NICU Babies Remember Harrowing Hurricane Night

Nurses at the Neonatal Intensive Care Unit at New York University’s Langone Medical Center have challenging jobs, even in the best of times. Their patients are babies, some weighing as little as 2 pounds, who require constant and careful care as they struggle to stay alive.

On Monday night, as superstorm Sandy bore down on Manhattan, the nurses’ jobs took on a whole new sense of urgency as failing power forced the hospital’s patients, including the NICU nurses’ tiny charges, to evacuate.

“20/20″ recently reunited seven of those nurses: Claudia Roman, Nicola Zanzotta-Tagle, Margot Condon, Sandra Kyong Bradbury, Beth Largey, Annie Irace and Menchu Sanchez. They described how they managed to do their jobs – and save the most vulnerable of lives – under near-impossible circumstances.

On Monday night, as Sandy’s wind and rain buffeted the hospital’s windows, the nurses were preparing for a shift change and the day nurses had begun to brief the night shift nurses. Suddenly, the hospital was plunged into darkness. The respirators and monitors keeping the infants alive all went silent.

For one brief moment, everyone froze. Then the alarms began to ring as backup batteries kicked in. But the coast wasn’t clear – the nurses were soon horrified to learn that the hospital’s generator had failed, and that the East River had risen to start flooding the hospital.

Vanishing America: Jersey Shore Boardwalks Washed Away Watch Video

“Everybody ran to a patient to make sure that the babies were fine,” Nicola Zanzotto-Tagle recalled. “If you had your phone with a flashlight on the phone, you held it right over the baby.”

For now, the four most critical patients – infants that couldn’t breathe on their own – were being supplied oxygen by battery-powered respirators, but the clock was ticking. They had, at most, just four hours before the machines were at risk of failing.

Annie Irache tended to the most critical baby — he had had abdominal surgery just the day before – as an evacuation of 20 NICU babies began.

“[He] was on medications to keep up his blood pressure,” Irache said, “and he also had a cardiac defect, so he was our first baby to go.”

One by one, each tiny infant, swaddled in blankets and a heating pad, cradled by one nurse and surrounded by at least five others, was carried down nine flights of stairs. Security guards and secretaries pitched in, lighting the way with flashlights and cell phones.

The procession moved slowly. As nurses took their careful steps, they carefully squeezed bags of oxygen into the babies’ lungs.

“We literally synchronized our steps going down nine flights,” Zanzotto-Tagle said. “I would say ‘Step, step, step.”

With their adrenaline pumping, the nurses said, it was imperative that they stay focused.

“We’re not usually bagging a baby down a stairwell … n the dark,” said Claudia Roman. “I was most worried about, ‘Let me not trip on this staircase as I’m carrying someone’s precious child, because that would be unforgivable.”

When the medical staff and the 20 babies emerged, a line of ambulances was waiting. A video of Margot Condon cradling a tiny baby as she rode a gurney struck a chord worldwide. But Condon said she had a singular goal.

“I was making sure the tube was in place, that the baby was pink,” she said. “I was not taking my eyes off that baby or that tube.”

Like other nurses, she did not feel panic. Her precious patient helped keep her calm.

Health News Headlines – Yahoo! News

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Colin Firth, Michael Fassbender set for A. Scott Berg adaptation ‘Genius’

LOS ANGELES (TheWrap.com) – Colin Firth and Michael Fassbender will star in “Genius,” directed by Michael Grandage, with Film Nation handling international sales, the company announced on Thursday.

Based on A. Scott Berg‘s biography “Max Perkins: Editor of Genius,” the tells the story of the relationship between Thomas Wolfe (Fassbender) and editor Max Perkins (Firth), the screenplay is written by John Logan.

“Genius” will be produced by James Bierman for the Michael Grandage Company, launched at the end of 2011 by Grandage, the former artistic director of London’s Donmar Warehouse. Bierman served as executive producer at Donmar and co-formed MGC with Grandage. MGC is producing Logan’s new play, “Peter and Alice,” to be directed by Grandage, as part of a season of plays in London in Spring 2013.

FilmNation is selling the film at the AFM. CAA will arrange the financing and represent the film’s North American distribution rights. Principal photography is scheduled to start early in 2014.

Movies News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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Romney, Obama look for edge as campaign nears end

PORTSMOUTH, N.H. (AP) — Three days. Nine states — give or take. A magic 270 electoral votes. For President Barack Obama and rival Mitt Romney, the final touch-and-go stretch of campaigning is down to the numbers.

New hiring reports or a new jobless rate. Spending totals or early vote totals. Percentage points and rhetorical points. Frequency of stops or size of crowds. In a game of metrics, each camp is looking for that last measure that will separate them at the finish line.

After holding mostly small and mid-size rallies for much of the campaign, Obama's team is planning a series of larger events this weekend aimed at drawing big crowds in battleground states. Still, the campaign isn't expecting to draw the massive audiences Obama had in the closing days of the 2008 race, when his rallies drew more than 50,000.

Obama's closing weekend also includes two joint events with former President Bill Clinton: a rally Saturday night in Virginia and an event Sunday in New Hampshire. The two presidents had planned to campaign together across three states earlier this week, but that trip was called off because of Superstorm Sandy. And, of course, there is always Ohio, the top battleground of them all.

In a whiff of 2008 nostalgia, some of Obama's traveling companions from his campaign four years ago were planning to join him on the road for the final days of his last campaign. Among them are Robert Gibbs, who served as Obama's first White House press secretary, and Reggie Love, Obama's former personal aide who left the White House earlier this year.

Not to be outdone, Romney hosted a massive rally Friday night in West Chester, Ohio, drawing more than 10,000 people to the Cincinnati area for an event that featured rock stars, sports celebrities and dozens of Republican officials. It was a high-energy event on a cold night designed to kick off his own sprint to the finish.

Romney arrived in New Hampshire close to midnight on Friday after an 18-hour day on the campaign trail that took him from Virginia to Wisconsin to Ohio. He was attending a morning rally on the New Hampshire seacoast before making an afternoon appearance in Iowa, and two more in Colorado. He shifted an original plan to campaign in Nevada on Sunday in favor of a schedule likely to bring him back to Iowa, Ohio, Pennsylvania and Virginia.

Aides stress that his schedule is fluid and may change with little notice as they evaluate where his time is best spent.

On Saturday, Obama's first stop was in Mentor, Ohio, then he was campaigning in Milwaukee and Dubuque, Iowa, and ending the day in Bristow, Va. On Sunday, he was taking his campaign to New Hampshire, Florida, Colorado and, yes, Ohio.

Polling shows the race remains a toss-up heading into the final days. But Romney still has the tougher path; he must win more of the nine most-contested states to reach 270 electoral votes: Ohio, Florida, Virginia, North Carolina, Colorado, Nevada, Wisconsin, Iowa and New Hampshire.

Romney has added Pennsylvania to the mix, hoping to end a streak of five presidential contests where the Democratic candidate prevailed in the state. Obama won Pennsylvania by more than 10 percentage points in 2008; the latest polls in the state give him a 4- to 5-point margin. Romney will campaign in the Philadelphia suburbs on Sunday. Obama aides scoff at the Romney incursion, but they are carefully adding television spending in the state and are sending Clinton to campaign there Monday.

The final frenzy of campaigning comes in the wake of Superstorm Sandy that has dominated much of the news coverage for the past several days as New York, New Jersey and Connecticut recover from the brunt of its force. Friday also offered an economic finale to the campaign with the release of October jobs reports that contained better than average economic news but gave both campaigns a talking point. Employers added a better-than-expected 171,000 jobs last month, but the jobless rate ticked up to 7.9 percent from 7.8 percent — mainly because more people jumped back into the search for work.

In crucial early voting, Obama holds an apparent lead over Romney in key states. But Obama's advantage isn't as big as the one he had over John McCain four years ago, giving Romney hope that he could make up that gap in Tuesday's election.

About 25 million people already have voted in 34 states and the District of Columbia. No votes will be counted until Election Day, but several battleground states are releasing the party affiliation of people who have voted early. So far, Democratic voters outnumber Republicans in Florida, Iowa, Nevada, North Carolina and Ohio. Republicans have the edge in Colorado.

___

Kuhnhenn reported from Washington. Associated Press writers Julie Pace and Stephen Ohlemacher contributed to this report.

Follow Jim Kuhnhenn on Twitter at: https://twitter.com/jkuhnhenn

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Painkillers not as addictive as feared: study

NEW YORK (Reuters Health) – Fewer than five percent of patients prescribed narcotics to treat chronic pain become addicted to the drugs, according to a new analysis of past research.

The finding suggests that concerns about the risk of becoming addicted to prescription painkillers might be “overblown,” said addiction specialist Dr. Michael Fleming at Northwestern University’s Feinberg School of Medicine.

“If you’re a person that doesn’t have a history of addiction and doesn’t have any major psychiatric problems, narcotics are relatively safe as long as your doctor doesn’t give you too much and uses the right medication,” Fleming, who was not involved in the new study, told Reuters Health.

Some recent research has concluded the same thing, but another expert remained skeptical about the new report because many of the studies it included were not considered the best quality research, and they varied widely in their results.

“I think the jury’s still out” on how worrisome prescription opioid addiction is, said Joseph Boscarino of the Geisinger Clinic in Danville, Pennsylvania, who studies pain and addiction.

Opioid painkillers, which include oxycodone, fentanyl and morphine, have only recently become available for patients with chronic pain, said Boscarino, who was not part of the new study.

In the past, the drugs were almost exclusively reserved for cancer patients and people with short-term pain – on the theory that in the first category of patients the need outweighed the risk, and in the second group, short term use was unlikely to lead to long-term addiction.

“They opened up (to chronic pain patients), and since then there’s been a wave of addiction, especially in the last five years,” Boscarino said.

One recent study found that the number of people diagnosed with a substance abuse problem increased by 70 percent from 2001 to 2009, and doctors suspect the increased popularity of prescription painkillers is a primary driver (see Reuters Health story of October 22, 2012).

Of course, not all these cases reflect patients who are using the drugs as directed – or who even have a prescription to treat chronic pain.

To get a sense of how addictive opioid painkillers are for those patients who do have a prescription, researchers from The Cochrane Collaboration, an independent group that reviews research on medications, collected the results from 17 studies covering more than 88,000 people.

All of the patients had been prescribed opioids to treat chronic pain, and nearly all of them had pain unrelated to cancer.

In 10 of the studies, patients used the painkillers for anywhere from three months to several years, while one study included just short-term use of several days and the others did not report the length of time patients were on the drugs.

Taken together, the studies found that 4.5 percent of people developed a dependency on the painkillers.

“It’s a low percentage,” said Dr. Silvia Minozzi, lead author of the study and a member of the Cochrane Drugs and Alcohol Group in Rome.

Although 4.5 percent was the most common rate of addiction among the studies, Minozzi pointed out there were large differences in the rates each study found – ranging from zero to 31 percent.

For instance, a study by Boscarino and his colleagues that was included in Minozzi’s review found that 25 percent of patients became addicted.

The group of patients Boscarino surveyed had a high rate of alcoholism and illegal drug use, though.

He said the disparities among the various studies could also be a result of how people were surveyed about their behaviors.

“We surveyed the patients about their pain in their homes (where) they were relaxed,” he said. “I think they were more inclined not to try to hide their symptoms.”

Minozzi’s review found that, among the three studies with information on substance abuse, people with a history of drug use were more likely than other patients to develop an addiction to their prescription pain pills.

For most people, addiction “does happen, but it’s not very common,” Fleming told Reuters Health. “But if you give a big bottle of Percocets to someone who has an addiction history, who may or may not be using cocaine and marijuana at the same time, they have pain and maybe they should be treated, but they’re much more likely to get into trouble with that.”

Knowing this can help physicians screen patients to judge who might be the most vulnerable to becoming addicted and get them into the appropriate interventions, he said.

Minozzi noted the fact that her review found a “deficiency of good-quality” studies on this subject, “seems to stand in contrast to the widespread concern of doctors and authorities relating to the prescription of opioids for pain.”

SOURCE: http://bit.ly/U0ye5P Addiction, online October 18, 2012.

Medications/Drugs News Headlines – Yahoo! News

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“The Man with the Iron Fists” review: RZA serves up half-baked chop-socky

LOS ANGELES (TheWrap.com) – Homage is a tricky thing – you can be full of love for the object of your tribute, and recreate its trappings with accuracy and sincerity, but that doesn’t mean your results will match the original.

Take “The Man with the Iron Fists,” the first film directed by RZA, founding father of legendary hip-hop combo the Wu-Tang Clan. From the name of his group to the look of his movie, this is a guy who has clearly watched a whole lot of vintage martial-arts movies. If I were on “Who Wants to Be a Millionaire?” and my multiple-choice answers were down to “Five Deadly Venoms” and “The 36th Chamber of Shaolin,” this is the guy I’d want for my lifeline.

I’d even hire him to create one of those fake trailers in “Grindhouse,” since he clearly appreciates the pacing and the acting style of the Shaw Brothers kung fu classics of the 1970s. Instead, RZA hooked up with “Grindhouse”-meisters Eli Roth (who co-wrote “Fists”) and Quentin Tarantino (who “presents” this new film) to create this full-on, feature-length homage.

The blood spurts, the knives shoot out, and the fists fly – but “The Man with the Iron Fists” never takes off. As the old saying goes, RZA knows the words, but he doesn’t know the music.

He’s also not actor enough to tackle the pivotal role he’s given himself, as Blacksmith in Jungle Village, a tiny hamlet beset by various warring clans. Blacksmith just wants to liberate his lover Lady Silk (Jamie Chung) from the brothel owned by Madam Blossom (Lucy Liu), but instead he must forge weapons for members of the Lion and Fox clans.

The Lions have problems of their own – engaged by the emperor to protect a shipment of gold, second-in-command Silver Lion (Byron Mann) assassinates Gold Lion (Kuan Tai Chen) with the intent of stealing the gold. Word of his treachery reaches Gold Lion’s son Zen Yi (Rick Yune), who returns to Jungle Village seeking vengeance.

Meanwhile, mysterious Englishman Jack Knife (Russell Crowe) shows up at Madam Blossom‘s with a vast array of appetites – and an even more varied collection of weapons.

Word is that RZA originally had a four-hour cut that he hoped to release in two parts, “Kill Bill”-style, but instead was forced to slash his vision down to 90 minutes. That might excuse the choppiness of the plot and exposition, but it doesn’t explain why the fighting scenes are so listless and the acting (with the notable exception of Liu and Crowe, who were smart enough to create their own amusement) so stiff.

Regarding the latter, the performances aren’t even bad in an homage-to-the-bad-acting-of-the-original way; they’re just dull and not ironically so. As for the action sequences, the choreography and camera movements suggest 1970s chop-socky, but they are simulacra under glass — it’s like watching a bad high school production of “West Side Story,” where the Jets and the Sharks are clearly never going to hurt each other.

(The midnight audience that watched the film with me didn’t whoop or laugh a single time during these gory but bloodless melees.)

The one fresh idea that “The Man with the Iron Fists” has – namely, to contrast the 18th century settings with contemporary hip-hop music – is quickly abandoned; after the first one or two fight scenes, we’re back to very generic scoring. The film also might have scored points for allowing the African-American Blacksmith character to exist in feudal China without explaining how he got there…but no, they explain it, in a tedious flashback that adds little except an all-too-brief cameo by an exploitation legend.

If RZA wanted to host a retrospective of kung fu classics, I’d be first in line. But his admiration for the genre doesn’t translate into capably executing it himself.

Movies News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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Read More..

Bloomberg cancels marathon amid outcry

Eric Gordon will be out 4-6 weeks with a knee injury reports Yahoo! Sports' @SpearsNBAyahoo --> http://t.co/JXGOWjyv

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UK cost agency backs melanoma drugs after price cuts

LONDON (Reuters) – Two new drugs for skin cancer have been recommended for use on Britain’s state-run health service after the rival manufacturers – Roche and Bristol-Myers Squibb – agreed to cut their prices.

The move underscores the growing pressure on drug companies to cut deals with austerity-hit European governments in order to prove their expensive new medicines offer value for money.

The National Institute for Health and Clinical Excellence (NICE) said on Friday it had issued final draft guidance recommending both Roche’s Zelboraf and Bristol‘s Yervoy after the companies offered undisclosed discounts.

NICE, which determines if products should be used by the National Health Service (NHS), had initially rejected both medicines, despite acknowledging that they represented a breakthrough in treating melanoma.

The list price for Zelboraf, which is only suitable for patients with a particular genetic profile, is 52,500 pounds ($ 84,600) for an average treatment span of seven months.

The price of a four-dose course of Yervoy, which is recommended only for people who have received prior chemotherapy, is 75,000 pounds.

($ 1 = 0.6207 British pounds)

(Reporting by Ben Hirschler; Editing by Mark Potter)

Medications/Drugs News Headlines – Yahoo! News

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Judge throws out lawsuit against Britney Spears and parents

LOS ANGELES (Reuters) – A Los Angeles judge on Thursday dismissed a lawsuit by the one-time confidante of pop star Britney Spears, ruling there was insufficient evidence to go forward with the trial on allegations of defamation, assault and breach of contract.

“I really thought long and hard. It’s the right thing to do, so I am going to do it,” Los Angeles Superior Court Judge Suzanne Bruguera said, announcing her decision to throw out the case after hearing two weeks of evidence in the civil trial.

Bruguera’s ruling was a major victory for Spears and her family, despite damaging and sometimes humiliating testimony that lifted the lid on the singer’s controversial career and personal meltdown five years ago.

Sam Lutfi, the self-styled manager of the pop star for a brief period in 2007 and early 2008, had sued Spears’ mother, Lynne Spears, for defaming him in her 2008 book “Through the Storm.” Lynne Spears wrote that Lutfi controlled her daughter, cut her telephone lines and tried to cut the star off from her family.

Bruguera also dismissed claims filed by Lutfi against Spears. He said the singer hired him as her manager after they met in a nightclub in 2007, and he was entitled to a portion of her earnings.

Lutfi case against Spears’ father, Jamie Spears, was also thrown out. Lutfi alleged that Jamie Spears punched him in 2008 while the singer was in a Los Angeles psychiatric ward.

Lutfi, 38, said he would appeal the ruling.

Spears, 30, has since staged a comeback with world tours, hit albums and a new job as judge on Fox’s TV talent show “The X-Factor.” She did not attend the trial.

In testimony last week, Lutfi sobbed on the witness stand, saying he received death threats because of the villainous portrayal of him in the book. He also claimed he tried to get Spears off drugs and protect her from paparazzi photographers who hounded her day and night.

His most sensational claim was that Spears shaved her head in February 2007 because she feared her hair could be tested for drug use in her bitter child custody battle with ex-husband Kevin Federline.

Lutfi also told the court that he brought drug-sniffing dogs to her home and flushed a bag of white powder down the toilet.

Jamie Spears’ attorney told the court that his client was afraid that his daughter would die from drug abuse and believed that Lutfi was making her problems worse.

Lynne Spears testified that Lutfi crushed up drugs and put them into the singer’s food to help her sleep.

Spears’ meltdown led to her father’s conservatorship, which gives him legal control over her finances and health.

(Editing by Jill Serjeant and Stacey Joyce)

Music News Headlines – Yahoo! News

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Apple rolls out iPad mini in Sydney to shorter lines

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Fuel scarce as East Coast struggles to recover

NEW YORK/SEASIDE HEIGHTS, New Jersey (Reuters) - Rescuers searched flooded homes for survivors, drivers lined up for hours to get scarce gasoline and millions remained without power on Thursday as New York City and nearby towns struggled to recover from one of the biggest storms to hit the United States.

New York subway trains crawled back to limited service after being shut down since Sunday, but the lower half of Manhattan still lacked power and surrounding areas such as Staten Island, the New Jersey shore and the city of Hoboken remained crippled from a record storm surge and flooding.

At least 95 people died in the "superstorm" that ravaged the Northeastern United States on Monday. Officials said the number could rise as rescuers searched house-by-house in coastal towns.

"I worked all my life, and everything I had is right there," said Bob Stewart, 59, standing on the Jersey Shore beach in the town of Seaside Heights and looking at the pile of debris that was once his home. "I put my life right there."

New Jersey Governor Chris Christie said on Thursday that nearly a 1,000 people had been rescued by authorities.

In blackened New York City neighborhoods, some residents complained there was a lack of police and feared an increase in crime. Some were also concerned about traffic safety. New York police officials were not immediately available to comment.

"People feel safe during the day but as soon as the sun sets, people are extremely scared. The fact that Guardian Angels are on the streets trying to restore law just shows how out of control the situation is in lower Manhattan," said Wolfgang Ban, owner of Edi & The Wolf restaurant in Manhattan's Alphabet City neighborhood.

The Guardian Angels are a group of anti-crime volunteers.

More than 15 people in the borough of Queens were charged with looting, and a man was charged on Thursday with threatening another driver with a gun after he tried to cut in on a line of cars waiting for gas, Queens District Attorney Richard Brown said.

The financial cost of the storm promised to be staggering. Disaster modeling company Eqecat estimated Sandy caused up to $20 billion in insured losses and $50 billion in economic losses, double its previous forecast.

At the high end of the range, Sandy would rank as the fourth costliest U.S. catastrophe ever, according to the Insurance Information Institute, behind Hurricane Katrina in 2005, the September 11, 2001, attacks and Hurricane Andrew in 1992.

POWER OUT, GAS SHORTAGE

The presidential campaign was back in full swing on Thursday after being on hold for several days because of the storm. President Barack Obama, locked in a tight race with Republican challenger Mitt Romney head of next Tuesday's election, appeared to gain politically from his disaster relief performance.

Christie, a vocal Romney supporter, praised Obama, and New York Mayor Michael Bloomberg, a political independent, endorsed Obama on Thursday.

In New York, U.N. headquarters suffered severe damage and U.N. Secretary-General Ban Ki-moon offered recovery help to the United States and Caribbean nations affected by the storm.

The hunt for gasoline added to a climate of uncertainty as Sandy's death toll and price tag rose.

"I'm so stressed out," said Jessica Bajno, 29, a teacher from Elmont, Long Island, who was waiting in line for gas. "I've been driving around to nearby towns all morning, and being careful about not running out of gas in the process. Everything is closed. I'm feeling anxious."

Some residents may lack electricity for weeks. New York utility Consolidated Edison restored power to 250,000 customers, with 650,000 others still in the dark.

The vast majority will be restored by the weekend of November 10-11, but "the remaining customer restorations could take an additional week or more," the company said.

Advertising creative director Chris Swift, 37, lost power in his apartment in Manhattan's Chelsea district on Monday and by Thursday he was so fed up he got on a bus to Boston.

"I tried 20 (New York City) hotels on foot as couldn't call them with no battery left on my phone, but they were all booked. I tried to get to (friends in) Brooklyn but cabs would not take me as they we're running out gas," he said.

About 4.6 million homes and businesses in 15 U.S. states were without power on Thursday, down from a record high of nearly 8.5 million.

More deaths were recorded overnight in the New York borough of Staten Island, where authorities recovered 17 bodies after the storm lifted whole houses off their foundations. Among the dead were two boys, aged 4 and 2, who were swept from their mother's arms by the floodwaters, police said.

In all, 39 people died in New York City, officials said.

"It was like living through Titanic but on ground," said Krystina Berrios, 25, of Staten Island, looking at her bedroom caked in mud, furniture upended. "You would never think in a million years having to live through something like this."

JERSEY SHORE FLOORED

Sandy started as a late-season hurricane in the Caribbean, where it killed 69 people, before smashing ashore in the United States with 80-mile-per-hour (130-kph) winds. It stretched from the Carolinas to Connecticut and was the largest storm by area to hit the United States in decades.

In New Jersey, where entire neighborhoods in oceanside towns were swallowed by seawater and the Atlantic City boardwalk was destroyed, the death toll rose to 13.

Floodwaters receded from the streets of Hoboken, New Jersey, across the Hudson River from Manhattan, leaving behind a smelly mess of submerged basements and cars littering the sidewalks.

"The water was rushing in. It was like a river coming," said Benedicte Lenoble, a photo researcher from Hoboken. "Now it's a mess everywhere. There's no power. The stores aren't open. Recovery? I don't know."

New Jersey natives Bruce Springsteen and Jon Bon Jovi will headline a benefit concert for storm victims Friday on NBC television, the network announced.

The Federal Emergency Management Agency agreed to cover 100 percent of emergency power and public transportation costs through November 9 for affected areas of New York and New Jersey, up from the traditional share of 75 percent.

More than 36,000 disaster survivors from New York, New Jersey and Connecticut have applied for federal disaster assistance and more than $3.4 million in direct assistance has already been approved, White House spokesman Jay Carney said.

The Pentagon was airlifting power restoration experts and trucks from California to New York to assist millions of people still living in darkness.

Fuel supplies into New York and New Jersey were hit by idled refineries, a closed New York Harbor, damages to import terminals, and a closed oil pipeline.

The scarcity of fuel, electricity and supplies made cleanup more daunting for barrier towns.

Seaside Heights residents who obeyed the mandatory evacuation order were cut off from their homes. The entire community was submerged by the storm surge, which washed over the island and into the bay that separates it from the mainland.

Chris Delman, 30, saw a photograph of his house in a local newspaper on Wednesday. It was still standing.

"We ain't living in Seaside no more, that's obvious," Delman said. "I just want to know what I have left."

(Additional reporting by Reuters bureaus throughout the U.S. Northeast; Writing by Daniel Trotta and Michelle Nichols; Editing by Jim Loney and Peter Cooney)

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Sanofi draws fire over cost of MS drug Lemtrada

PARIS (Reuters) – Medical journal The Lancet warned that Sanofi‘s experimental multiple sclerosis drug Lemtrada may be too costly for patients and health insurers once it gets approved by regulators.

The journal, which published the encouraging results of two late-stage Lemtrada tests on Thursday, also criticized the drugmaker’s decision to withdraw leukemia therapy Campath, the same drug given at a different dosage, depriving MS patients who had been using it off-label.

In an editorial accompanying the test results, The Lancet voiced concerns that Lemtrada would be priced higher than current MS drugs on the market and said the discontinuation of Campath may mean patients who had used it for MS would not be able to continue their treatment.

The injectable drug, chemically known as alemtuzumab, was sold until September 2012 under the name Campath as treatment for leukemia and given more frequently at a higher dosage.

“There is concern that with a license for multiple sclerosis, the cost of alemtuzumab could rise and might become too expensive for many patients and health systems,” the editorial said.

Although Campath remains available free of charge to leukemia patients, Sanofi’s rare disease unit Genzyme pulled it off the market in September to prevent its unauthorized use as an MS drug.

Analysts said the move would allow the company to adjust the price to match that of rival MS drugs on the market.

A full course of Campath, which in 2011 had sales of $ 76 million, cost around $ 60,000 when given three times a week for up to 12 weeks, according to Genzyme.

Lemtrada, instead, is given at less than half the dose of Campath for 5 consecutive days and then again for 3 days a year later. Since the drug has yet to be approved, it remains unclear how much Sanofi will charge for it.

The drug, which works by resetting a person’s immune system, has shown in late-stage trials to be an effective treatment for MS patients who have failed to respond to other therapies.

It has also shown to benefit people not previously treated for the disease, suggesting it could be used as a first-line MS therapy.

But patients need regular monitoring for serious side effects that can include infections and autoimmune diseases.

“It’s important that the appropriate safety monitoring is in place for patients who are prescribed Lemtrada,” Genzyme’s head of MS, Bill Sibold, told Reuters, responding to questions about the Lancet editorial. “Until an approved risk-management program is established, we believe the use of Lemtrada should only occur in clinical trials.”

Lemtrada remains available to patients who are taking part in clinical tests.

Sibold declined to discuss pricing plans for Lemtrada, but said Genzyme has set up programs to make its approved drugs available to patients who cannot afford them. “With Lemtrada it would be no different,” he said.

DRUG FUNDING

But there are concerns that cash-strapped European governments may balk at funding the drug through their public healthcare systems.

Doug Brown, Head of Biomedical Research at U.K. charity MS Society said that while Lemtrada’s results are great news for patients, the drug would only be useful to them if it were available through the country’s publicly funded National Health Service.

“We urge Genzyme to price the treatment responsibly so that if it’s licensed, it’s deemed cost effective on the NHS,” he said.

The U.K.’s cost-effectiveness body National Institute for Health and Clinical Excellence (NICE), whose opinions are also watched closely in other countries, initially rejected Novartis’ MS pill Gilenya, only to make a U-turn after the company agreed to a discounted price.

Sanofi launched its MS pill Aubagio in the U.S. at a price of $ 45,000 for a year’s treatment, making it cheaper than rivals.

Gilenya – the only other MS pill currently on the market – costs 28 percent more, while injectable treatments such as Biogen Idec Inc’s Avonex and Teva Pharmaceutical Industries Ltd’s Copaxone are 8 and 6.5 percent higher respectively.

(Reporting by Elena Berton; Editing by Tim Dobbyn)

Medications/Drugs News Headlines – Yahoo! News

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Evan Rachel Wood marries “Billy Elliot” star Jamie Bell

LOS ANGELES (Reuters) – Hollywood actress Evan Rachel Wood has quietly married Briton Jamie Bell – star of the 2000 “Billy Elliot” dance movie – in a ceremony in California, Wood’s spokeswoman said on Wednesday.

“The bride wore a custom dress by Carolina Herrera. It was a small ceremony with close family and friends,” the spokeswoman said in a statement, adding that the wedding took place on Tuesday.

In a Twitter posting on Wednesday, Wood, best known for her roles in “The Wrestler” and coming of age movie “Thirteen,” said “Words cannot describe the happiness I am feeling. Overwhelming.”

Wood, 25, first began dating Bell about seven years ago. But the pair broke up and Wood went on to have a highly publicized engagement with heavy metal rocker Marilyn Manson, who is almost twice her age.

Wood and Bell, 26, were rumored to have become engaged in January this year, but never confirmed their relationship.

Bell found fame as the teen star of “Billy Elliot” about a ballet dancer growing up in a tough coal mining town in northern England. He won a British BAFTA award for the role and has since appeared in adventure movies like “The Eagle” and “Jumper.”

(Reporting By Jill Serjeant; Editing by Sandra Maler)

Movies News Headlines – Yahoo! News

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Apple's Cook fields his A-team before a wary Street

SAN FRANCISCO (Reuters) - Apple Inc Chief Executive Tim Cook's new go-to management team of mostly familiar faces failed to drum up much excitement on Wall Street, driving its shares to a three-month low on Wednesday.

The world's most valuable technology company, which had faced questions about a visionary-leadership vacuum following the death of Steve Jobs, on Monday stunned investors by announcing the ouster of chief mobile software architect Scott Forstall and retail chief John Browett -- the latter after six months on the job.

Cook gave most of Forstall's responsibilities to Macintosh software chief Craig Federighi, while some parts of the job went to Internet chief Eddy Cue and celebrated designer Jony Ive.

But the loss of the 15-year veteran and Jobs's confidant Forstall, and resurgent talk about internal conflicts, exacerbated uncertainty over whether Cook and his lieutenants have what it takes to devise and market the next ground-breaking, industry-disrupting product.

Apple shares ended the day down 1.4 percent at 595.32. They have shed a tenth of their value this month -- the biggest monthly loss since late 2008, and have headed south since touching an all-time high of $705 in September.

For investors, the management upheaval from a company that usually excels at delivering positive surprises represents the latest reason for unease about the future of a company now more valuable than almost any other company in the world.

Apple undershot analysts targets in its fiscal third quarter, the second straight disappointment. Its latest Maps software was met with widespread frustration and ridicule over glaring mistakes. Sources told Reuters that Forstall and Cook disagreed over the need to publicly apologize for its maps service embarrassment.

And this month, Apple entered the small-tablet market with its iPad mini, lagging Amazon.com Inc and Google Inc despite pioneering the tablet market in 2010.

Investor concerns now center around the demand, availability and profitability of new products, including the iPad mini set to hit stores on Friday.

"The sudden departure of Scott Forstall doesn't help," said Shaw Wu, an analyst with Sterne Agee. "Now there's some uncertainty in the management."

"There appears to be some infighting, post-Steve Jobs, and looks like Cook is putting his foot down and unifying the troops."

Apple declined to comment beyond Monday's announcement.

Against that backdrop, Cook's inner circle has some convincing to do. In the wake of Forstall's exit, iTunes maestro Eddy Cue -- dubbed "Mr Fixit", the sources say -- gets his second promotion in a year, taking on an expanded portfolio of all online services, including Siri and Maps.

The affable executive with a tough negotiating streak who, according to documents revealed in court, lobbied Jobs aggressively and finally convinced the late visionary about the need for a smaller-sized tablet, has become a central figure: a versatile problem-solver for the company.

Ive, the British-born award-winning designer credited with pushing the boundaries of engineering with the iPod and iPhone, now extends his skills into the software realm with the lead on user interface.

Marketing guru Schiller continues in his role, while career engineer Mansfield canceled his retirement to stay on and lead wireless and semiconductor teams. Then there's Federighi, the self-effacing software engineer who a source told Reuters joined Apple over Forstall's initial objections, and has the nickname "Hair Force One" on Game Center.

"With a large base of approximately 60,400 full-time employees, it would be easy to conclude that the departures are not important," said Keith Bachman, analyst with BMO Capital Markets. "However, we do believe the departures are a negative, since we think Mr. Forstall in particular added value to Apple."

TEAM COOK

Few would argue with Forstall's success in leading mobile software iOS and that he deserves a lot of credit for the sale of millions of iPhones and iPads.

But despite the success, his style and direction on the software were not without critics, inside and outside.

Forstall often clashed with other executives, said a person familiar with him, adding he sometimes tended to over-promise and under-deliver on features. Now, Federighi, Ive and Cue have the opportunity to develop the look, feel and engineering of the all-important software that runs iPhones and iPads.

Cue, who rose to prominence by building and fostering iTunes and the app store, has the tough job of fixing and improving Maps, unveiled with much fanfare by Forstall in June, but it was found full of missing information and wrongly marked sites.

The Duke University alum and Blue Devils basketball fan -- he has been seen courtside with players -- is deemed the right person to accomplish this, given his track record on fixing services and products that initially don't do well.

The 23-year veteran turned around the short-lived MobileMe storage service after revamping and wrapping it into the reasonably well-received iCloud offering.

"Eddy is certainly a person who gets thrown a lot of stuff to ‘go make it work' as he's very used to dealing with partners," said a person familiar with Cue. The person said Cue was suited to fixing Maps given the need to work with partners such as TomTom and business listings provider Yelp.

Cue's affable charm and years of dealing with entertainment companies may come in handy as he also tries to improve voice-enabled digital assistant Siri. He has climbed the ladder rapidly in the past five years and was promoted to senior vice president last September, shortly after Cook took over as CEO.

Both Cue and Cook will work more closely with Federighi, who spent a decade in enterprise software before rejoining Apple in 2009, taking over Mac software after the legendary Bertrand Serlet left the company in March last year

Federighi was instrumental in bringing popular mobile features such as notifications and Facebook integration onto the latest Mac operating system Mountain Lion, which was downloaded on 3 million machines in four days.

The former CTO of business software company Ariba, now part of SAP, worked with Jobs at NeXT Computer. Federighi is a visionary in software engineering and can be as good as Jobs in strategic decisions for the product he oversees, a person who has worked with him said.

His presentation skills have been called on of late, most recently at Apple annual developers' gathering in the summer.

Then there's Ive, deemed Apple's inspirational force. Among the iconic products he has worked on are multi-hued iMac computers, the iPod music player, the iPhone and the iPad.

Forstall's departure may free Ive of certain constraints, the sources said. His exit brought to the fore a fundamental design issue -- to do or not to do digital skeuomorphic designs. Skeuomorphic designs stay true to and mimic real-life objects, such as the bookshelf in the iBooks icon, green felt in its Game Center app icon, and an analog clock depicting the time.

Forstall, who will stay on as adviser to Cook for another year, strongly believed in these designs, but his philosophy was not shared by all. His chief dissenter was Ive, who is said to prefer a more open approach, which could mean a slightly different design direction on the icons.

"There is no one else who has that kind of (design) focus on the team," the person said of Ive. "He is critical for them."

(Additional reporting by Alistair Barr; Editing by Edwin Chan and Ken Wills)

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